he hospital was established by way of a merger of the Royal Orthopaedic Hospital (founded in 1840 and based in Hanover Square) and the National Orthopaedic Hospital (founded in 1836 and based in Great Portland Street) in August 1905. The City Orthopaedic Hospital (founded in 1851 and based in Hatton Garden) joined the merger in 1907.
New facilities for the merged entities were built on Great Portland Street and were opened by King Edward VII in July 1909. During the First World War, the hospital in Great Portland Street became an emergency hospital for the military and from early 1918 also accommodated discharged disabled soldiers. The Great Portland Street site continued to accommodate short-term in-patients after the war.
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